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The way that we conceptualise this is that if survival is long, and/or the treatment offers very large benefits, then the time spent pursuing treatment, you know, waiting in the chemotherapy unit, going for a CT scan, going to the emergency room because of vomiting after treatment, that time proportionately might be quite small, and for most patients it might be an easy trade-off decision Norman Swan : In other words, you're willing to invest in it for the upside