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Though nicotine is a poison, when people have a little bit of it, it can give them an excited feeling

Marijuana-derived CBD has higher THC levels, which may offer more potent effects, but it comes with more legal restrictions

Cotinine disposition and effects

Several detrimental consequences of chronic exposure have been reported, including ocular surface malignancies, alteration in tear film stability and quality, tear production and corneal epithelial thickness, loss of upper and lower eyelid meibomian glands, and dry eye symptoms or ocular irritation