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Indeed, more vitamin C is found in the epidermal layer than in the dermis, with differences of 25-fold between the two layers being consistently reported
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They pointed out that Astragalus can improve the expression of IL-6, IL-I, and TNF- after weaning, and improve the morphology of the jejunum villi (51)
However, their clinical translation is limited by potential limitations: 1) impaired tissue repair capacity due to senescent cell clearance, 2) off-target cytotoxicity to nonsenescent cells, and 3) transient inflammatory responses triggered by released cellular contents and inflammatory mediators
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