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[218] As a result, his signature line of guitars was pulled from production

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However, while medical product manufacturers are generally required to meet a standard of safety and effectiveness to receive premarket approval from FDA, tobacco product manufacturers are instead generally required to meet a standard of "appropriate for the protection of public health" to receive premarket approval

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Ehlers-Danlos syndrome (EDS) is a heterogeneous group of congenital connective tissue diseases caused by mutations in genes involved in the synthesis or processing of collagen fibers.1 The phenotypic manifestations of EDS vary greatly, and mild cases can go unnoticed until late in life