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Neuropeptide-expressing fibers, including those positive for SP and CGRP, interact with immune cells such as MCs to initiate neurogenic inflammation and promote the release of type 2 cytokines like IL-4 and IL-13, thereby exacerbating both cutaneous inflammation and pruritus (110)

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It may be asked, have the races who erected these extensive mounds become extinct, or do they exist in the poor uncivilized tribes of Indians whom Europeans found inhabiting the river valleys of Ohio and Illinois

Indirectly, yes