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Fibroblast-like synoviocytes (FLSs) contribute to pannus formation and matrix degradation through MMP-1 and MMP-3, with expression levels 5 - 10 times higher in RA synovium (Figure 1) (14)

& Kapur, R

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4 From mechanisms to applications: translational considerations for TME-oriented nanoplatforms The strategies discussed in previous sections are grounded in mechanistic insights and preclinical models

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