CRD42023385632) ( We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, adhering to the 4-phase flow diagram and the 27-item checklist for this study (see PRISMA reporting checklist) 6
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Many forms of tobacco use are associated with a significantly increased risk of morbidity and premature mortality due to tobacco-related diseases
One possible concern is whether this increased risk is due to older age among ever users, as COPD is a progressive disease that develops over time