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The decline in smoking over the past two decades has been one of the great public health achievements of the 21st century, but worsening air pollution has offset many of the expected gains in general respiratory health

Less saliva can reduce the buffering and movement of swallowed materials, and dehydration can alter digestion

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In line with this, exposure to 10% CSE and 12.5% CSE induced a ~2-3 fold increase protein levels of the anti-oxidant protein Manganese Superoxide Dismutase (Mn-SOD, Figure 3C), a marker of oxidative stress, with a similar increase in Mn-SOD expression upon exposure to 10% CSE and 12.5% CSE at the mRNA level (data not shown)