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Both alcohol and tobacco smoke induce certain cytochrome P450 enzymesparticularly CYP2E1 (by ethanol) and CYP1A2 (by tobacco smoke)which can lead to altered drug metabolism and increased production of toxic intermediates

There was only one problem: the incubator story was not true and the 15-year-old nurse turned out to be the daughter of the Kuwaiti ambassador to the US

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Withdrawal symptoms can include: Anxiety Depression Irritability Fatigue Intense drug cravings Withdrawal from cocaine is difficult and uncomfortable, which can make it hard to quit using the drug

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