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However, tobacco companies have undermined these measures by differentially over-shifting or under-shifting the tax increases, (i.e., increasing prices beyond the tax increase, or not applying the tax fully)

Different studies have found that certain genotypes (CYP1A1 and GSTT1) interact with smoking to modify the risk of preterm birth (PTD) 49,50

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The FDA also addressed concerns that Chantix may cause neuropsychiatric side effects, including suicidal thoughts