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Analytical technologies such as GC-MS and LC-MS/MS can detect compounds in urine at picogram-per-milliliter concentrations

Subsequent investigations indicated that MSU crystals targeted the NLRP3 inflammasome by suppressing macrophage miR-223 expression and facilitated the production of inflammatory cytokines, IL-1 and TNF- (43)

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Peer review Peer review information Communications Biology thanks Yoshitaka Isaka and the other, anonymous, reviewer(s) for their contribution to the peer review of this work