Low-quality evidence from two randomized controlled trials suggests that routine administration of probiotics, prebiotics, or synbiotics may provide minimal benefit for patients with primary hypothyroidism
Further, the numbers were 35% from anti-estrogenic substances (tamoxifen, clomiphene, fulvestrant, toremifene, and raloxifene) and 20% from AIs (letrozole, anastrozole, exemestane, adrostatrienedione, and armistane) in 2022 (World Anti-Doping Agency, 2024b)
And because this peptide combination is meant to be used consistently over weeks and months to see meaningful changes in body composition and sleep, anything that erodes nightly compliance directly undermines the results
It is also noted for its potential benefits in supporting digestive wellness, making it a versatile tool for overall health
The evidence base for tirzepatide as monotherapy is robust, with pivotal trials including SURMOUNT-1 demonstrating significant weight reduction in adults with obesity, and SURPASS trials establishing glycemic efficacy in type 2 diabetes