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In addition, e-cigarettes would be expected to increase risk of other combustible tobacco products per the catalyst hypothesis, which has been shown in several studies (Barrington-Trimis et al., 2016a

We did not test SFTPB, however, since there were no commercially available kits and it had been reported that SFTPB has a non-linear, J-shaped association with lung cancer risk (with no and high levels increasing risk), making interpretation of results difficult 23