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Therefore, multi-target comprehensive treatment for this axis holds significant translational potential and merits further exploration in clinical trials ( Single-cell omics unveils molecular lineages and remodeling mechanisms of the small airways In small airway stenosis, fibroblast-driven ECM remodeling is the core of structural stenosis, while persistent inflammation dominated by neutrophils and macrophages provides the cellular and enzymatic basis for this process (such as MMPs and ROS), promoting the degradation and redeposition of ECM ( Spirometry In the absence of a non-invasive gold standard for diagnosing small airway obstruction (SAD), traditional pulmonary function tests remain the most commonly used screening tool in clinical practice, mainly because they are easy to operate, reproducible and low-cost ( 3 /FEV 6 is below the lower limit (LLN), HRCT/PRM-defined gas trapping and functional small airways disease (fSAD) can be detected even in smokers with normal FEV 1 /FVC, suggesting that this simple and easily obtainable respiratory function indicator can help identify potential early small airways lesions ( 1 decline and adverse clinical outcomes during follow-up, which reinforced the value of imaging fSAD in early identification and risk stratification ( 3 /FEV 6 as a preliminary screening in high-risk smoking populations combined with imaging methods such as PRM can help to early identify and stratify the management of individuals with subclinical small airway disease
87) which imposed a ban on cigarette advertising on television and radio after September 30, 1970
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