Classic EDS is inherited in an autosomal dominant manner and is caused by mutations in COL5A1 or COL5A2, which encode the alpha-1 and alpha-2 chains, respectively, of collagen type V.1 The disease is characterized by skin hyperextensibility, joint hypermobility and associated complications (luxations, pain, early osteoarthritis), and other clinical characteristics that are reviewed in a recent international consensus paper.1 Dermatologic manifestations of classic EDS include skin hyperextensibility and abnormal scarring, which results the formation of atrophic scars with a cigarette-paper-like appearance
They measure 100mm in length, giving you plenty of room to enjoy your tobacco
Kato T, Umeda A, Miyagawa K, Takeda H, Adachi T, Toyoda S, et al
The study was published in the journal Addiction
Drinks: Include coffees mixed with cannabis, sodas, and teas