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Then, when the production began, the musical director and Garland were dismayed by the arrangement of the opening number and ordered it to be rewritten, along with several more scenes for Kelly, who Minnelli wanted to have more screen time

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A climate of generalized chronic inflammation is then created, characterized by an increase in several inflammatory markers (IL-6, CRP, ICAM) and the recruitment of immune cells to the surface of blood vessels, two phenomena that contribute to the development of atherosclerosis