All three are GH secretagogues that activate the GHS-R1a receptor, but they differ in selectivity: The choice depends on the research protocol: selectivity (ipamorelin), power (GHRP-2) or orexigenic effect (GHRP-6)
10.1016/j.addr.2013.07.007 59 KrainerF
It is proposed to work by binding GHRH receptors on pituitary somatotroph cells, prompting the pituitary to synthesize and release its own growth hormone in a pulsatile pattern, with the body's somatostatin feedback loop still intact so the effect is self-limiting rather than a constant hormone flood
Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui TN, et al
Indeed, renal clearance tends to correlate well with glomerular filtration rate, even for renally secreted drugs and, as mentioned previously, filtration scales well across species