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Visits occur during the day at the Penn State University College of Medicine Clinical Research Center in Hershey, PA and George Washington University Milken School of Public Health and Medical Faculty Associates in Washington, DC

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[32] HTPs generally heat tobacco to temperatures below 600 C (1100 F), [32] [11] [35] which is lower than the combustion temperature of conventional cigarettes

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However, these free radicals are also known clastogens (chromosome-breaking) and membrane-active agents thought to promote asbestos carcinogenicity through oxidative damage, directly and indirectly damaging DNA [75] , including oncogene activation and perturbation of cellular antioxidant processes