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Varenicline is the most effective monotherapy currently available a Cochrane network meta-analysis found it more than doubled sustained abstinence rates at 6 months follow-up, compared with placebo (risk ratio 2.88, 95% CI 2.403.47)

This report therefore uses only 11 major categories of cause of death, some of which are quite broad, and several of its main analyses are of all cause mortality

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