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In 2022, a systematic review by the University of Bath's Tobacco Control Research Group which receives funding from Bloomberg Philanthropies and are part of STOP, a global tobacco industry watchdog concluded that PMI's clinical trials of its heated tobacco products were of poor quality and at high risk of bias

Of those who still smoked tobacco at week 4, smoking had reduced from a baseline of 19.1 cigarettes/day to 8.7

The activity measured in the mainstream smoke represented 1.8 0.3% (n = 8) of the total 210 Po present in the Heets cigarettes while the activity measured in the side-stream represented about 8% of total 210 Po

doi: 10.1016/j.neuroscience.2011.01.032 45 HoyerDHannonJPMartinGR