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Nicotine, being an addictive substance, can lead to cravings and dependence

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A prospective therapeutic drug monitoring study showed that steady-state plasma olanzapine concentration/dose ratio closely correlated with CYP1A2 metabolic activity, and described a statistically significant five-fold lower dose-corrected steady-state plasma olanzapine concentration in smokers [21]

Moreover, the quality of life of individuals with and without IBS was neither measured nor compared