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Unlike machines, human smokers are often heavily addicted to the nicotine in cigarettes, and consequently, smokers alter their smoking behaviors in order to consume the amount of nicotine required to satisfy their cravings

Unfortunately, a large share of laboratory studies generating vape aerosols (to test emissions or expose in vivo and in vitro systems) do not follow a puffing standard, which makes it difficult to compare experimental outcomes

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Stronger tobacco requires equally structured drinks to maintain balance