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This browning is mediated through multiple pathways including SIRT1/PGC-1 activation, increased expression of thermogenic genes (UCP1, PRDM16, PPAR), and enhanced mitochondrial biogenesis

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Most individuals with raised serum B12 remain asymptomatic, and the elevation serves primarily as a biochemical marker that may warrant further investigation

Supports neuroprotection and longevity through effects on oxidative stress, neuroinflammation, and cellular senescence