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Smokeless tobacco showed a positive association with 8 of the 9 outcomes, showing that CHD mortality had a hazard ratio (HR) of 1.31 (95% CI, 1.08-1.59), CVD mortality had an HR of 1.23 (95% CI, 1.07-1.41), and myocardial infarction had an HR of 1.20 (95% CI, 1.03-1.39)

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Modliszewski, Dillon E

More work is still needed to elucidate the biological targets that could indicate depression-nicotine dependence comorbidity

It traveled from industrial Pittsburgh, Pennsylvania, where it was built, with stops at Wheeling, West Virginia