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Associations between the timing of maternal cigarette smoking and birth congenital anomalies Maternal cigarette smoking before pregnancy or during either trimester was significantly associated with six subtypes of congenital anomalies: congenital diaphragmatic hernia, gastroschisis, limb reduction defect, cleft lip with or without cleft palate, cleft palate alone, and hypospadias

Journal of the Royal College of Physicians of London , 27 (3), 315319