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The Center for Disease Control (CDC) notes that cannabis "use beginning in teen years or younger may affect brain development which may impair thinking, memory, and learning.' Additionally, people were more likely to develop cannabis use disorder when their first use of cannabis occurred as an adolescent

Archived from the original on 24 August 2020

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Heavy smokers may need to take frequent puffs or use efficient devices (e.g., pod systems or sub-ohm mods) to ensure they get enough nicotine

This is likely to produce similar synergistic effects to actually mixing the two together (many do so for the perceived experience of getting more high as a result)