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Example titration on a 20 mg vial reconstituted with 3.0 mL BAC water (~6.67 mg/mL) Example planning titration only Days Days 15 Daily dose 1.0 mg Units on U-100 syringe 15 units Volume 0.15 mL Days Days 614 Daily dose 1.5 mg Units on U-100 syringe 22.5 units Volume 0.225 mL Days Days 1520 Daily dose 2.0 mg Units on U-100 syringe 30 units Volume 0.30 mL Example planning math only, not a dosing recommendation

Additionally, under stress or disease conditions, such as hypoxia, cellular senescence can be induced

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Scand J Rheumatol (1997) 26:3017