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Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning

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In vitro mouse MCs, ex vivo human skin explants, and in vivo murine models have demonstrated that pharmacological activation of GluK2 significantly inhibits MCs degranulation as well as cutaneous inflammatory and pruritic responses, supporting its potential as a negative regulatory therapeutic target (138)

For example, e-cigarette use was significantly associated with smoking cessation (adjusted odds ratio [OR], 1.63