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Whats happening: Collagen remodeling is accelerating, the extracellular matrix is being restructured with new collagen fibers

Also, serum LDH, which is a known marker of pulmonary cellular damage, was higher in the acute exacerbation of IPF group than in the non-IPF group and mortality within 12 weeks was relatively higher in the former group 32

High-intensity exercise can lead to a temporary imbalance between the active oxygen/nitrogen species production and removal, which can lead to oxidative stress