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In 1961, cigarettes peaked at 61% of all American adults being smokers and then gradually declined to 12% in 2020

This category represents a dynamic shift in consumer preference toward novelty and sensory experiences

Changes in clinical variables and mitral flow Doppler indices after caffeine assumption, cigarette smoking, or both in comparison with baseline are shown in Table 2

The funding agencies played no role in the design of the study, data collection, data analysis and interpretation, or in the writing of the manuscript