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Many of the toxic compounds in smoke are not present in the tobacco before it burns, but are created in chemical reactions when the tobacco is heated or burned

An overview of studies previously published or provided to authorities is documented in a recent report from the German Institute for Standardisation ( FIGURE 1 In 2007, the United States (US) National Research Council ( in silico , in chemico , in vitro , and ex vivo approaches ( With the growth and increasing variants of non-combustible TNCPs, regulatory requirements have changed or are under development in several nations

This item is not recommended for Children under 3 years, and advises supervision for ages 9 and under

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