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In embryofetal developmental studies, clozapine had no effects on maternal parameters, litter sizes, or fetal parameters when administered orally to pregnant rats and rabbits during the period of organogenesis at doses up to 0.4 and 0.9 times, respectively, the MRHD of 900 mg/day on a mg/m2 body surface area basis

Unopened Cigarettes: When kept in their sealed, original packaging and stored in a cool, dark place, cigarettes can last up to 12 months

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Harrington, president of Liggett & Myers Tobacco Co