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Lastly, febuxostat restored the MCA reactivity in the third trimester and full-term-exposed male rats while females, once again, displayed no differences

have previously demonstrated that cigarette smoke exposure decreases zonula occludens (ZO)-1 and ZO-2 proteins, leading to the disruption of epithelial tight junction integrity, which may be the cause of our observed decrease in transepithelial electrical resistance 23

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[201] [202] Natural analogues [edit] Natural analogues of nicotine, often found in plants or other biological sources, include anabasine (from Anabasis aphylla), anatabine (from tobacco), arecoline (from betel nut), cotinine (major metabolite of nicotine), cytisine (from Laburnum species), and epibatidine (from frog skin), among others