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The integrative medicine community can help by demanding the substances that drive the industry are managed in a way that provides responsible access to peptides with proper protection for patients, which requires some kind of reasonable regulations and expectation for quality control

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Chitosan-based hydrogels can be modified with pH-responsive polymers to facilitate controlled drug release in the acidic environment of tumors

As a typical damage-associated molecular pattern (DAMP) molecule, HMGB1 can mediate heat stress-induced NLRP3 inflammasome activation via the TLR4 and receptor for advanced glycation end products (RAGE) signaling pathways, thereby promoting IL-1 activation and inducing hepatocyte pyroptosis, ultimately leading to severe liver injury in rats [26]