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Reward Pathway Activation : Nicotines repeated activation of the brains reward pathway leads to neuroadaptations, where the brain becomes less responsive to natural rewards

Ethanol causes acute inhibition of carbohydrate, fat and protein oxidation and insulin resistance

Nicotine releases chemicals in your brain that make you feel good

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Nausea : Some individuals often experience feelings of nausea or gastrointestinal discomfort as their body adjusts to the absence of nicotine