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If you are a smoker and you believe that using an e-cigarette for a short period of time to help you completely quit combustible tobacco might be something you want to try

found an IC50 of 42 M for nicotine with OCT2 expressed in Xenopus oocytes ( In vivo experiments have demonstrated that nicotine can induce the activity of various enzymes within the central nervous system (CNS), including CYP2E1, CYP2A1/2A2, and CYP2B1/2B2 (Zevin and Benowitz, 1999)

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Biochemical pharmacology 78: 668676