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Wang H, Li N, Chivese T, Werfalli M, Sun H, Yuen L, et al

Phosphorylase kinase predominantly phosphorylates and activates glycogen phosphorylase, the enzyme responsible for removal of glucose from glycogen

To overcome drug resistance and enhance its cytotoxicity, two derivatives of DOX were synthesized incorporating a sulfonamide moiety: 4-mononitrobenzenesulfonyl DOX (MNS-DOX) and 2,4-dinitrobenzenesulfonyl DOX (DNS-DOX) 94

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(2010) 28:e13042