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The pleiotropic effects of tobacco smoke on the immunostimulatory function of DCs are further illustrated by a study reporting a diminished capacity of DCs from cigarette smoke-exposed mice to induce IL-2 production by T cells, which was associated with a decreased antigen-specific T-cell proliferation in vivo

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What is clear is that an outright prohibition of tobacco-based products does not create successful outcomes, with more measured and informative campaigns being more effective