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Once absorbed, nicotine enters the bloodstream and binds to receptors in the human nervous system, including the brain, triggering an array of reversible physiological responses (e.g., a transient increased heart rate and blood pressure)

Kim and Coulombe, 2010)

Vaping research is ongoing, but it's clear that it delivers detectable levels of nicotine/cotinine

Abstract A wide range of electronic cigarette (EC) devices, from small cigarette-like (first-generation) to new-generation high-capacity batteries with electronic circuits that provide high energy to a refillable atomizer, are available for smokers to substitute smoking