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Aqueous solution of nicotine in a 10-ml spray bottle 50 L spray / 0.5mg nicotine per metered dose ~100 doses/bottle Rapid absorption across nasal mucosa NICOTINE NASAL SPRAY DOSAGE SUMMARY One dose is equal to 2 sprays (1 per nostril) (0.5 mg/spray or 1 mg/dose) Usual dose follows a 14 week schedule Weeks 1-8, start with 1 or 2 doses per hour for 6 to 8 weeks, but at least 8 doses per day Weeks 9-14, gradually reduce over 4 to 6 weeks

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Despite these findings, further analysis confirmed that the association between PTE and childhood tobacco experimentation was not mediated by the childs current environment or current maternal tobacco exposure [157]

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