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2.3.1.1 Self-reported consumption patterns by age A person who smokes a pack-a-day smokes 20 or more cigarettes per day

These pathways may contribute to synovitis, disturb synovium-cartilage crosstalk, and promote joint degeneration in susceptible individuals, although direct OA-specific evidence remains limited, particularly for EC exposure

Case-series studies were categorized based on the percentage of Yes answers in the JBI checklist as: low risk of bias (33%), moderate risk of bias (3466%), or high risk of bias (67%) 11