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It's not unusual for the symptoms of B12 deficiency to get worse when treatment starts - part of the repair effect - and irritability / mood issues are know symptoms of B12 deficiency, so this may explain your reaction to the B12 shots

BREAKWATER: Randomized phase 3 study of encorafenib (enco) + cetuximab (cet) chemotherapy for first-line treatment (tx) of BRAF V600E-mutant (BRAFV600) metastatic colorectal cancer (mCRC)

This method bypasses digestive breakdown, resulting in potential benefits such as improved bioavailability, rapid absorption and reliable clinical data outcomes

PMID 22128128

And more - but the right hyperpigmentation treatment can help