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This finding may reflect several biological mechanisms including: 1) baseline protease levels were not necessarily zero and may be elevated due to subclinical inflammation or recent nicotine exposures

It is also true that smoking is a social habit, this being the reason why so many people like to smoke when going out

For these reasons, I respectfully urge the Agency to incorporate illicit-market substitution effects into its evaluation of MRTP applications and to weigh whether timely authorization of qualifying products accompanied by appropriate post-market oversight may better advance the statutory goal of improving population health than continued regulatory limbo