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The use of pharmacotherapies such as varenicline when combined with other behavioral treatment interventions (such as proactive telephone counseling and Web-based delivery, or both) is cost effective when measured from both cost per LY and cost per QALY, with costs per additional 6-month nonsmoker and per additional life time quitter ranging from US$1,278 to US$1,617 and from US$2,601 to US$3,291, respectively