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These options may be considered as third-line or adjunctive options in selected patients with HS, particularly those with metabolic syndrome or those with moderate-to-severe cases (statement 33), and should always be used with close monitoring for adverse effects

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HPV detection and typing methods Testing for HPV was conducted by using a PCR-reverse dothybridization technology, with the help of a PCRRDB HPV genotyping assay (Yaneng Bioscience Co., Ltd., China) 13