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Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis

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Evidence to support this theory lies in the demonstration that the endosomal/lysosomal compartment is the key site of A oligomerization in neurons where oligomerization is enhanced 8,000 times in these conditions of low pH compared to the extracellular compartment where they may be released (Schtzmann et al., 2021)

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