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Hippocampal interneurons expressing glutamic acid decarboxylase and calcium-binding proteins decrease with aging in Fischer 344 rats

The hypothesis that was put forth was that analogs are binding directly to HGF and affecting the sequestration of HGF in an inactive form

Intraperitoneal administration in animal models shows a shorter half life (one to two hours) because the peritoneal membrane allows faster systemic absorption and subsequent liver exposure