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2e Non-linear gradients It is not always desirable to use a linear gradient and either convex, concave, S-shaped or more complex gradient density profiles may be required to effect a particular resolution of particles

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For example, Motus by Tonum (oral) reported about 10.4% average weight loss in human clinical trials over six months

However, metabolic pathways are not simple one-way roads, rather they are part of a complex network of interactions