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Such regional atrophy may result from the deleterious impact of cigarette smoking and/or reflect predisposing neurobiological, neurocognitive, or personality factors

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It is caused by dominant pathogenic variants in KRT139 or KRT10.40 - Superficial keratinopathic ichthyosis shows a milder phenotype than the 2 previous ones and does not present erythroderma at birth

This causes inflammation and symptoms such as changes in bowel movements and pain

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