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It is sometimes used as an insecticide because of its sharp microscopic particles damage the exoskeletons of insects, causing them to dehydrate and die

Correspondence Published: Bone Marrow Transplantation volume 55 , pages 18441846 (2020) Cite this article 696 Accesses 5 Citations 5 Altmetric Metrics details Subjects Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) affecting the oral cavity in 4583% of cases [1]

Yes pure nicotine is a deadly poison, but there is a very old phrase in toxicology the dose makes the poison the often added clich (source) is that even water is toxic if you drink enough of it

Journal of Neuromuscular Diseases, 6 (1), 9397

Bottom graph, At 0 mV, GABA neurons from nicotine treated animals (red) demonstrated a significantly greater rate of eIPSC amplitude depression than GABA neurons from saline-treated animals (black)